HIV–1 resistance to dolutegravir: update and new insights

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HIV–1 resistance to dolutegravir: update and new insights

Integrase strand transfer inhibitors (INSTIs) are the latest class of potent anti-HIV drugs. Currently, three INSTIs have been approved by the US Food and Drug Administration: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Resistance mutations to RAL and EVG emerge rapidly, and significant cross-resistance between these compounds has been documented. In addition, limited cross-re...

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ژورنال

عنوان ژورنال: Journal of Virus Eradication

سال: 2015

ISSN: 2055-6640

DOI: 10.1016/s2055-6640(20)31150-x